Revvity Gr125743,

Revvity GR125743 acts as an antagonist at serotonin 5-HT_1B and 5-HT_1D receptors. These receptors belong to a class of serotonin GPCRs and are potential drug targets for depression and anxiety. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity References for NET1172: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Golnasim Riahi, Marc Morissette, Pershia Samadi, Martin Parent, Thérèse Di Paolo, Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia, In Biochemical Pharmacology, Volume 86, Issue 7, 2013, Pages 970-978.