Revvity Ifenprodil, -, 250µci (9.25mbq)

Revvity Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. These receptors are glutamate receptors and ion channel proteins in nerve cells, and are potential drug targets for neurodegeneration, analgesia, memory disorders, and Parkinsons disease. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity References for NET1089: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Jukka Kupila, Olli Kärkkäinen, Virpi Laukkanen, Merja Häkkinen, Hannu Kautiainen, Jari Tiihonen, Markus Storvik, [3H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study, In Psychiatry Research: Neuroimaging, Volume 231, Issue 3, 2015, Pages 197-201.Z. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells, In Neuroscience, Volume 159, Issue 4, 2009, Pages 1397-1407.