Revvity HTRF Human and Mouse Ataxin 2 Detection Kit, 500 Assay Points

Ataxin 2 is an RNA-binding protein. In humans, Ataxin 2 causes neurodegeneration when carrying very long polyglutamine tract and drives disease progression in ALS. Current research in neurodegenerative and specifically ALS settings indicates there is a modulation of Ataxin 2 expression by TDP-43, which in turns sees its toxicity in cellular and animal models modified by Ataxin 2. The co-investigation of both proteins is a relevant topic for future therapeutic endeavours, with recent results indicating that lowered Ataxin 2 levels suppress TDP-43 aggregation.