Revvity Human Il23/Il23r Binding

Revvity IL23 is part of the response against infection, as it upregulates the expression of MMP9 (matrix metalloprotease 9), increases angiogenesis, and reduces CD8 T cell infiltration into tumors. In oncology and immuno-oncology, IL23 has been studied for its effects on T cell infiltration and its promotion on TH17 cell development. Anti IL23 antibodies have also been developed for the treatment of Crohns Disease and psoriasis. IL23 is a heterodimeric cytokine composed of p19 and p40 subunits, and which binds the heterodimeric IL23R, IL12Rβ1 complex. The Human IL23-IL23R assay is highly specific for IL23/IL23R, and hence is especially suitable for the discovery and characterization of anti p19 antibodies. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)