Revvity Htrf Human Vhl Binding Kit, 10000 Tests

Revvity A fast and easy way to identify new binders to VHL protein. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity VHL, also known as von Hippel-Lindau, is involved in many biological processes and is closely associated with the regulation of angiogenesis, cell growth, or cell survival. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity VHL is one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity VHL interacts with several proteins to form the functional von Hippel-Lindau ubiquitination complex, in which VHL seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex, and targets various proteins to proteolysis such as the hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Therefore, identifying new PROTAC VHL ligands can improve selective proteasomal-dependent degradation of proteins of interest, involved in the onset of diseases such as cancers. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)