Revvity Human Aq Sting Binding Kit, 500 Tests

Revvity A fast and easy way to identify new binders to human AQ STING. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173), is a protein playing a major role in innate immunity. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity The AQ and HAQ variants are found in respectively 5.2% and 20.4% of the world population. Both variants display the same binding pocket, since the R71H mutation is part of the transmembrane domain, and not expressed in the recombinant protein. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Upon intracellular cytosolic DNA release from pathogens such as viruses and bacteria, 2’-3’cGAMP binds to STING protein and triggers the secretion of type 1 interferon. The AQ variant shows a strong affinity to natural 2-3cGAMP and other known compounds. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Identifying new STING ligands is therefore a way to control immunity and fight autoinflammatory diseases. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)