Revvity HTRF Human and Mouse Phospho-HDAC5 Ser259 Detection Kit, 500 Assay Points

Histone deacetylases (HDACs) regulate chromatin remodeling and subsequent gene transcription by controlling the status of histone acetylation. Histone deacetylation induces a condensed chromatin conformation, thus contributing to the repression of gene transcription, which is involved in diverse physiological processes.

HDAC5 belongs to class IIa HDACs, including HDAC4, HDAC7, and HDAC9. It plays a key role in the control of cellular proliferation, differentiation, migration, apoptosis, and metabolism.