Revvity HTRF Hman and Moe LC3B-II Detection Kit, 500 Aay Point

Revvity LC3 is a mammalian homolog of the yeast ATG8 protein and is distributed throughout mammalian tissues and cultured cells. LC3 is a key component of the autophagy process - a degradative program that maintains cellular homeostasis. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity During autophagy, cytoplasmic components such as cytosolic proteins and organelles are engulfed by autophagosomes Concurrently, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II). This newly formed conjugate is recruited to autophagosomal membranes. The subsequent fusion of autophagosomes with lysosomes results in the formation of autolysosomes, and intra-autophagosomal components are degraded by lysosomal hydrolases. At the same time, LC3-II within the autolysosomal lumen is degraded. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity The LC3-II level has been found to be proportional to autophagosome abundance making LC3-II the most popular marker of autophagy. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)