Revvity HTRF Human Total BRD2 Detection Kit

BRD2 belongs to the bromodomain (BRD) Family II (BET). Like the other BRD family proteins, it binds to acetylated lysine and acts as a reader of the lysine acetylation state of proteins such as histones. It is a transcriptional regulator involved in many cell processes (embryogenesis, cycle regulation, development) through the E2F-RB pathway. BRD2 dysregulation is has been widely linked to many cancers, as it regulates the transcription of several oncogenes such as c-MYC ad Bcl-2.

Thus, inhibition of the BRD2 function has become part of the strategy for cancer treatments. More recently, targeting BET family protein degradation, including BRD2 via PROTAC molecules, has emerged as a novel and promising therapeutic approach.