Revvity HTRF Human Total cGAS Detection Kit, 10,000 Assay Points

Following pathogen infection and the binding of dsDNA to the cytoplasmic sensor cGAS, STING protein is phosphorylated by TBK1, enabling its binding to IRF3 which leads to IFNs type 1 production. The STING pathway is then switched off by STING degradation, involving autophagy.

In immuno-oncology, activating the STING pathway has shown promising anti-tumor effects in pre-clinical models and thus represents a therapeutic strategy to treat human cancer.