Revvity HTRF Human Phospho-ATM Ser1981 Detection Kit, 10,000 Assay Points

Revvity This HTRF cell-based assay enables the rapid, quantitative detection of ATM phosphorylated at Serine 1981, as a readout of the ATM/CHK2 signaling pathway upon a DNA damage response (DDR). This kit is complementary to the phospho CHK2 Thr68 for studies of the ATM-CHK2 pathway. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity In response to DNA damage, such as Double Strand Breaks (DSBs), the ATM€“Chk2 pathway and replication checkpoint responses are activated. These mediate G1/S checkpoints to arrest cell cycle progression and allow extra time for DNA repair. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity In response to DNA DSBs, ATM autophosphorylates to generate the active monomeric kinase. Activation of ATM results in the phosphorylation of a diverse array of downstream targets such as H2A histone family member X, H2Ax, or the checkpoint kinase Chk2 and its downstream effectors. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)