Revvity Htrf Total Mlkl Cellular Kit

List Price $14,291.55 Your Price $14,291.55

Revvity The Total Mlkl Kit Is Designed To Monitor The Expression Level Of Cellular Mlkl, And Can Be Used As A Normalization Assay For The Phospho-Mlkl (Ser358) Kit. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

NETA PART: REVPFZ-64MLKLTPEH

MFG.PART: 64MLKLTPEH

UNSPSC: 41106509

Manufacturer: Revvity

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Revvity MLKL (Mixed lineage kinase domain-like protein) is a key mediator of apoptotic and necrotic cell death, as well as of inflammatory pathways downstream from TNFR1 and other receptors. MLKL is phosphorylated at Serine 358 by RIPK3, and is considered to be a biomarker of the initiation of RIPK1/RIPK3-dependent necroptosis. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Necroptosis is a programmed necrotic cell death pathway, also called "inflammatory cell death", which is closely associated with pathologies including inflammatory and neurodegenerative diseases, as well as cancer. MLKL has therefore become an important drug target for the pharmaceutical industry. Therapeutic strategies consist in developing specific small-molecule kinase inhibitors, such as the well-known Necrostatin-1 and Necrostatin-1s. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)