Revvity HTRF Human Phospho-Cyclin D1 Thr286 Detection

Revvity This HTRF cell-based assay conveniently and accurately detects phosphorylated Cyclin D1 at Thr286. ​​​​​​​ - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Cyclin D family members (including Cyclin D1, Cyclin D2, and Cyclin D3) are important regulators of cell cycle progression. They are integral mediators of growth factor-dependent G1 to S phase progression by playing the role of allosteric regulators of CDK4/6. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Cyclin D1 is upregulated in presence of extracellular mitogenic stimuli, and is then rapidly downregulated by proteasomal degradation following its phosphorylation on Thr286 by the kinase GSK-3β. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Cyclin D1 is an oncogene whose overexpression results in dysregulated CDK4/6 activity and leads to tumorigenesis. Cyclin D1 overexpression may be caused by gene amplification or chromosomal rearrangements, or as a result of impaired degradation of the protein. Mutations and deletions affecting its phosphorylation on Thr286 have been reported in several human cancers. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)