Revvity Total Cdk4 Cellular Kit, 10000 Tests

Revvity The Total CDK4 cellular assay monitors CDK4 protein levels. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity CDK4 (Cyclin-Dependent Kinase 4) is a member of the subfamily of CDKs that coordinate cell cycle progression in mammalian cells (including also CDK1, CDK2, and CDK6). In the early G1 phase of the cell cycle, CDK4 is activated by interaction with Cyclin D, and mono-phosphorylates the tumor suppressor RB (protein of retinoblastoma), leading to the transcription of genes required for G1/S phase transition. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Dysregulated activation of CDK4, leading to uncontrolled cell division, is a hallmark of cancers. Inhibition of CDK4 is thus an active research area, especially since the emergence of new approaches involving PROTACs (PROteolysis TArgeting Chimeras). - REVPFZ (Additional S&H Or Hazmat Fees May Apply)