Revvity HTRF Hman Androgen Recetor Fll Length Detection Kit, 10,000 Aay Point

The HTRF Human Full Length Androgen Receptor detection assay monitors Wild-Type Androgen Receptor (AR-WT) i.e. full length (AR-FL). It is used to detect the expression of endogenous or overexpressed AR-FL within various cells.

The Androgen Receptor is a nuclear receptor that is activated by androgen hormones, including testosterone (T) and Dihydrotestosterone (DHT).

Androgens bind to the ligand binding domain of the Androgen Receptor, resulting in receptor homodimerization and translocation to the nucleus. Downstream gene expression and signaling pathways are then activated, including the PI3K/AKT pathway. The gene expression induced by the Androgen Receptor promotes cell division, proliferation, differentiation, apoptosis, and angiogenesis. Dysregulation of the Androgen Receptor pathway can lead to oncogenic phenotypes, with Androgen Receptor activation or subexpression having been linked to conditions such as prostate cancer, breast cancer, glioblastoma, and other malignancies. Moreover, Androgen Receptor variants are expressed in various human cancer cell lines. The development of PROTAC compounds that target the degradation of the Androgen Receptor is a popular therapeutic strategy for targeting Androgen Receptor-positive cancers.