Revvity Kinase-Biotin Binding Di

Revvity ​The best known kinase inhibitor, Gleevec (Imatinib), binds a non-activated form of Abl. Such inhibitors are therefore more difficult to detect using activity based assays, SO it is worthwhile to set up kinase binding assays for your kinase of interest in order to avoid missing out on such compounds. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Moreover the HTRF® kinase binding assays are easily set up, using a mix and measure detection format in the absence of ATP. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Direct displacement of the fluorescent-inhibitor from the ATP binding pocket is measured, enabling the determination of the affinity of your inhibitor by performing dose response curves. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Purified kinase preparation is less critical compared to enzymatic assays, since measurements can be performed on kinases which have little or no activity. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)