Revvity AlphaLISA SureFire Ultra Human Total SMARCA2 Detection Kit, 100 Assay Points

SMARCA2 (Probable global transcription activator SNF2L2), a member of the SWI/SNF family, plays a crucial role in chromatin remodeling and DNA damage repair. It serves as an ATPase subunit within the SWI/SNF complex, which regulates genes involved in DNA replication and cell proliferation. Notably, SMARCA2 and SMARCA4 are well-established in SMARCA4-deficient cancers, where SMARCA2 inactivation leads to tumor cell death. Considering its potential, SMARCA2 could be targeted for protein degradation therapeutics in cancer treatment.

The AlphaLISA SureFire Ultra Human Total SMARCA2 Detection Kit is a sandwich immunoassay for the quantitative detection of total SMARCA2 in cellular lysates, using Alpha technology.

Formats:

The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

Cell and tissue lysatesAntibody modulatorsBiotherapeutic antibodies

Alpha SureFire kits can be used for:

Cellular kinase assaysReceptor activation studiesHigh-throughput drug screening