Revvity Phospho Rsk1 (Thr573) Alpha Surefire Ultra Det Kit

Revvity Serine/threonine-protein kinase acts downstream from ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81, and NR4A1/NUR77. It regulates translation through RPS6 and EIF4B phosphorylation and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing the pro-apoptotic function of BAD and DAPK1. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Upon extracellular signal or mitogen stimulation, RSK1 is phosphorylated at Thr-573 in the C-terminal kinase domain (CTD) by MAPK1/ERK2 and MAPK3/ERK1. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity The AlphaLISA™ SureFire® Ultra™ Phospho-RSK1 (Tyr573) assay is a sandwich immunoassay for quantitative detection of phospho-RSK1 in cellular lysates using Alpha Technology. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Formats: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

Revvity AlphaLISA SureFire Ultra kits are compatible with: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Cell and tissue lysatesAntibody modulatorsBiotherapeutic antibodies

Revvity Alpha SureFire kits can be used for: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Cellular kinase assaysReceptor activation studiesScreening