Revvity AlphaLISA SureFire Ultra Human and Mouse Phospho-LRRK2 (Ser955) Detection Kit, 10,000 Assay Points

Revvity Leucine-rich repeat kinase 2 (LRRK2, Dardarin, or PARK8) is a large, multifunctional kinase enzyme, classified as a member of the ROCO superfamily. The ROCO family is characterized by the presence of tandem Ras of complex (Roc) g-domain, kinase domains, and carboxy- terminal of Roc (COR) sequence which links them. LRRK2 plays a role in lysosomal function and the innate immunity in the brain (microglia activation) and modulates Tau phosphorylation via GSK-3b. Mutations in LRRK2 are associated with Parkinson’s disease. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity The AlphaLISA SureFire Human and Mouse Phospho-LRRK2 (Ser955) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-LRRK2 (Ser955) in cellular lysates, using Alpha Technology. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Formats

The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with

Cell and tissue lysatesAntibody modulatorsBiotherapeutic antibodies

Alpha SureFire kits can be used for

Cellular kinase assaysReceptor activation studiesScreening