Revvity AlphaLISA SureFire Ultra Human Phospho-MERTK (Tyr749) Detection Kit, 10,000 Assay Points

Mer receptor tyrosine kinase (MERTK) is a member of the TAM receptor family, playing a pivotal role in inflammatory responses, phagocytosis, and the clearance of apoptotic debris. Upon binding ligands such as Gas6 and protein S, MERTK undergoes dimerization and autophosphorylation, activating downstream pathways like PI3K/AKT and MAPK. Overexpression of MERTK is implicated in cancers, including leukemia and melanoma, while its modulation has therapeutic potential in autoimmune conditions.

The AlphaLISA SureFire Ultra Human Phospho-MERTK (Tyr749) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-MERTK in cellular lysates, using Alpha Technology.

Formats:

The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

Cell and tissue lysatesAntibody modulatorsBiotherapeutic antibodies

AlphaLISA SureFire Ultra kits can be used for:

Cellular kinase assaysReceptor activation studiesHigh-throughput screening for preclinical studies - REVPFZ (Additional S&H or Hazmat Fees May Apply)