Sigma-Aldrich NANOFABTX(TM)- RGD LIPID MIX FOR SYNTH&

NanoFabTx^™ RGD Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing RGD functionalized liposomes or lipid nanoparticles. RGD is a peptide composed of arginine, glycine, and aspartic acid (Arg-Gly-Asp).

RGD has high affinity to integrins (including alpha V beta 3) which are overexpressed on cancer cells such as glioma, ovarian cancer, breast cancer, pancreatic cancer to name a few. RGD conjugated lipids can be used to prepare liposomes to achieve targeted delivery of the anti-cancer agents to the cells which overexpress these receptors. The cells will internalize the RGD containing peptide via integrin-mediated endocytosis. As a result, the targeted liposomes avoid off target effects, a major side effect of many cancer therapies.

The RGD-functionalized liposomes synthesized from the NanoFabTx^™ RGD Lipid Mix enable users to 1) encapuslate a wide variety of small molecules and 2) selectively target cells which overexpress RGD-binding integrins, such as cancer cells, without the need for lengthy trial-and-error optimization.

• A ready-to-use lipid blend for the synthesis of RGD targeted liposomes
• Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
• Flexible synthesis tool to create uniform and reproducible liposomes
• RGD ligand enables targeted drug delivery

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol
• A microfluidics protocol using commercial platforms or syringe pumps

The microfluidics protocol included with this product uses the NanoFabTx^™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the Protocol section of this page.

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC