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Sigma-Aldrich ligand pomalidomide Quality Level 100 assay ≥95.0% form powder or crystals color
List Price $226.00 Your Price $226.00
Sigma-Aldrich ligand pomalidomide Quality Level 100 assay ≥95.0% form powder or crystals color off-white to light yellow storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)
NETA PART: SIALUPENN-934232-50MG
MFG.PART: 934232-50MG
UNSPSC: 41122409
Manufacturer: Sigma-Aldrich
ligand
pomalidomide
Quality Level
100
assay
≥95.0%
form
powder or crystals
color
off-white to light yellow
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CC5(CNC5)C4)C=C31)=O
InChI
1S/C18H18N4O4/c23-14-4-3-13(15(24)20-14)22-16(25)11-2-1-10(5-12(11)17(22)26)21-8-18(9-21)6-19-7-18/h1-2,5,13,19H,3-4,6-9H2,(H,20,23,24)
InChI key
ZJRIIJGHSAJWMI-UHFFFAOYSA-N
Application
Pomalidomide-2,6-diazaspiro[3.3]heptane Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
pictograms
GHS08
signalword
Danger
hcodes
H360D
pcodes
P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIALUPENN-934232-50MG |
|---|---|
| Supplier Part Number | 934232-50MG |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |