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Sigma-Aldrich ligand pomalidomide Quality Level 100 assay ≥ 95.0% form powder or crystals color fain
List Price $211.00 Your Price $211.00
Sigma-Aldrich ligand pomalidomide Quality Level 100 assay ≥ 95.0% form powder or crystals color faint yellow to dark yellow storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)
NETA PART: SIALUPENN-934275-50MG
MFG.PART: 934275-50MG
UNSPSC: 41122409
Manufacturer: Sigma-Aldrich
ligand
pomalidomide
Quality Level
100
assay
≥ 95.0%
form
powder or crystals
color
faint yellow to dark yellow
storage temp.
2-8°C
SMILES string
O=C1NC(=O)C(N2C(=O)C3=CC=CC(=C3C2=O)N4CCNCC4)CC1
InChI key
APURBVBIOACKLC-UHFFFAOYSA-N
Application
A functionalized cereblon ligand for development of Pomalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination; and a basic building block for making protein degrader library.
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Technology Spotlight:
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Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations; Inc.; and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
pictograms
GHS08
signalword
Danger
hcodes
H360D
pcodes
P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIALUPENN-934275-50MG |
|---|---|
| Supplier Part Number | 934275-50MG |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |