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Sigma-Aldrich Quality Level 100 assay ≥95.0% form semisolid color off-white to light yellow storage
List Price
$19.10
Your Price
$19.10
Sigma-Aldrich Quality Level 100 assay ≥95.0% form semisolid color off-white to light yellow storage temp. 2-8°C SMILES string O=C(OC(C)(C)C)N1CCC(CCN)CC1 InChI - SIALUPENN (Additional S&H or Hazmat Fees may Apply)
NETA PART:
SIALUPENN-934283-100MG
MFG.PART:
934283-100MG
UNSPSC:
41122409
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥95.0%
form
semisolid
color
off-white to light yellow
storage temp.
2-8°C
SMILES string
O=C(OC(C)(C)C)N1CCC(CCN)CC1
InChI
1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9,13H2,1-3H3
InChI key
LBQDLHPFISVBRU-UHFFFAOYSA-N
Application
A semi-flexible linker useful for PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of PROTACs may impact degradation kinetics as well as drug design (absorption; distribution; metabolism; excretion; and toxicity; ADMET) properties of PROTACs.
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Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations; Inc.; and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
pictograms
GHS07
signalword
Warning
hcodes
H302
pcodes
P264 - P270 - P301 + P312 - P501
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIALUPENN-934283-100MG |
|---|---|
| Supplier Part Number | 934283-100MG |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |