Sigma-Aldrich ligand thalidomide Quality Level 100 assay ≥95.0% form powder or crystals storage temp

Name: Sigma-Aldrich ligand thalidomide Quality Level 100 assay ≥95.0% form powder or crystals storage temp
SKU: SIALUPENN-934291-50MG
Price: 143.00 USD

List Price $143.00 Your Price $143.00

Sigma-Aldrich ligand thalidomide Quality Level 100 assay ≥95.0% form powder or crystals storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-934291-50MG

MFG.PART: 934291-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

ligand

thalidomide

Quality Level

100

assay

≥95.0%

form

powder or crystals

storage temp.

2-8°C

SMILES string

O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

InChI

1S/C23H30N4O6.C2HF3O2/c24-12-5-3-1-2-4-6-13-25-19(29)14-33-17-9-7-8-15-20(17)23(32)27(22(15)31)16-10-11-18(28)26-21(16)30;3-2(4,5)1(6)7/h7-9,16H,1-6,10-14,24H2,(H,25,29)(H,26,28,30);(H,6,7)

InChI key

AJVLNIUPDHKOPS-UHFFFAOYSA-N

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H312,H360D

pcodes

P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c