Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string

Name: Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string
SKU: SIALUPENN-934402-50MG
Price: 143.00 USD

List Price $143.00 Your Price $143.00

Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string N1CCC(CC1)c2cc3c(cc2)C(=O)N(C3=O)C4CCC(=O)NC4=O InChI - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-934402-50MG

MFG.PART: 934402-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

N1CCC(CC1)c2cc3c(cc2)C(=O)N(C3=O)C4CCC(=O)NC4=O

InChI

1S/C18H19N3O4/c22-15-4-3-14(16(23)20-15)21-17(24)12-2-1-11(9-13(12)18(21)25)10-5-7-19-8-6-10/h1-2,9-10,14,19H,3-8H2,(H,20,22,23)

InChI key

KOGMQASWKIDFRN-UHFFFAOYSA-N

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERGSmall-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c