Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string

Name: Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string
SKU: SIALUPENN-934410-100MG
Price: 79.00 USD

List Price $79.00 Your Price $79.00

Sigma-Aldrich Quality Level 100 assay ≥95% form powder storage temp. 2-8°C SMILES string N1(CCNCC1)CCNC(=O)OC(C)(C)C InChI - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-934410-100MG

MFG.PART: 934410-100MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

N1(CCNCC1)CCNC(=O)OC(C)(C)C

InChI

1S/C11H23N3O2/c1-11(2,3)16-10(15)13-6-9-14-7-4-12-5-8-14/h12H,4-9H2,1-3H3,(H,13,15)

InChI key

VPOIPCJBJNWHSJ-UHFFFAOYSA-N

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c