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Microneedles are a platform for transdermal drug delivery. The advantages of microneedles include the delivery of large molecules, painless and less invasive administration of the active pharmaceutical ingredient (API), ease of administration, and improved drug delivery including dose, delivery rate and efficacy. Microneedles are also effective for vaccine delivery due to the abundance of immune cells in the dermis. These microneedle templates can be used to make reproducible and high quality microneedle patches for a variety of therapeutics.

Transdermal delivery of a variety to therapeutics including:

• Nucleic acid delivery
• Vaccine delivery
• Protein or peptide delivery
• Small molecule delivery

Microneedle templates are exclusively made for producing dissolvable microneedle patches with excellent quality and repeatability. These templates are made of silicone rubber which is extremely durable, and chemical and heat resistant.

Microneedle template properties:

• Silicone Template
• Material: PDMS
• Patch Size (D): 8mm x 8mm
• Array Size: 10 x 10
• Needle Height (A): 700 µm
• Needle Base (B): 200 µm
• Needle Pitch (C): 500 µm
• Length of last microneedle cavity to the edge of the patch (F) can be calculated using the following formula: F = (patch size - [(n-1) x pitch)] / 2 where n = number of microneedles in one array
• Sterilization: Autoclave (optional)
• No. of use: repeated use if clean and stored properly

Suggested instructions for use:

1. Ensure the microneedle template is clean by washing with mild soap and letting them air dry completely
2. Pipette a small quantity (50-100 µL) of the drug mixture onto the microneedle template
3. Subject the template to centrifugal force for >60 seconds to ensure that all microneedle cavities are completely filled. The speed and duration are proportional to the viscosity of the matrix material and the volume of microneedle cavities to fill. Complete filling can be confirmed by observing the microneedle cavities under microscope (20x). No air bubbles are present for complete filling.