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Sigma-Aldrich Quality Level 100 assay ≥95% form powder or crystals color off-white to beige storage
List Price
$293.00
Your Price
$293.00
Sigma-Aldrich Quality Level 100 assay ≥95% form powder or crystals color off-white to beige storage temp. 2-8°C SMILES string Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)C3CCNCC3)CC1 InChI - SIALUPENN (Additional S&H or Hazmat Fees may Apply)
NETA PART:
SIALUPENN-936464-50MG
MFG.PART:
936464-50MG
UNSPSC:
41122409
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥95%
form
powder or crystals
color
off-white to beige
storage temp.
2-8°C
SMILES string
Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)C3CCNCC3)CC1
InChI
1S/C16H20FN3O2.ClH/c17-13-9-11(19-14-3-4-15(21)20-16(14)22)1-2-12(13)10-5-7-18-8-6-10;/h1-2,9-10,14,18-19H,3-8H2,(H,20,21,22);1H
InChI key
VJQKECGXGMCYHY-UHFFFAOYSA-N
Application
A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachment via reductive amination, and a basic building block for making protein degrader library.
Technology Spotlight:
targeted protein degradation
When used with other protein degrader building blocks
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
targeted protein degradation
When used with other protein degrader building blocks
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIALUPENN-936464-50MG |
|---|---|
| Supplier Part Number | 936464-50MG |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |