Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder color white to light yellow stor

Name: Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder color white to light yellow stor
SKU: SIALUPENN-936472-50MG
Price: 100.00 USD

List Price $100.00 Your Price $100.00

Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder color white to light yellow storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-936472-50MG

MFG.PART: 936472-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

ligand

VH032

Quality Level

100

assay

≥95%

form

powder

color

white to light yellow

storage temp.

2-8°C

SMILES string

C([C@@H](NC(CCCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

InChI

1S/C28H38N4O6S/c1-17-24(39-16-30-17)19-11-9-18(10-12-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)7-5-6-8-23(35)36/h9-12,16,20-21,25,33H,5-8,13-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1

InChI key

DKSZOQIYZOVHOL-TYBLODHISA-N

Application

(S, R, S)-AHPC-pentanoic-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c