Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder or crystals color White to Beige

Name: Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder or crystals color White to Beige
SKU: SIALUPENN-936529-50MG
Price: 207.00 USD

List Price $207.00 Your Price $207.00

Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form powder or crystals color White to Beige storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-936529-50MG

MFG.PART: 936529-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

ligand

VH032

Quality Level

100

assay

≥95%

form

powder or crystals

color

White to Beige

storage temp.

2-8°C

SMILES string

C([C@@H](NC(CCOCCOCCOCCOCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

InChI

1S/C34H50N4O10S/c1-23-30(49-22-36-23)25-7-5-24(6-8-25)20-35-32(43)27-19-26(39)21-38(27)33(44)31(34(2,3)4)37-28(40)9-11-45-13-15-47-17-18-48-16-14-46-12-10-29(41)42/h5-8,22,26-27,31,39H,9-21H2,1-4H3,(H,35,43)(H,37,40)(H,41,42)/t26-,27+,31-/m1/s1

InChI key

WCMFOLDVYYDUGD-FMVCKAMOSA-N

Application

(S,R,S)-AHPC-CO-PEG4-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c