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Sigma-Aldrich ligand thalidomide Quality Level 100 assay ≥95% form powder or crystals (or Solid or
List Price
$220.00
Your Price
$220.00
Sigma-Aldrich ligand thalidomide Quality Level 100 assay ≥95% form powder or crystals (or Solid or Chunks) color faint yellow to yellow, and Yellow-Green storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)
NETA PART:
SIALUPENN-936545-50MG
MFG.PART:
936545-50MG
UNSPSC:
41122409
Manufacturer:
Sigma-Aldrich
ligand
thalidomide
Quality Level
100
assay
≥95%
form
powder or crystals (or Solid or Chunks)
color
faint yellow to yellow, and Yellow-Green
storage temp.
2-8°C
SMILES string
O=C(O)CCOCCOCCNC1=CC=C2C(=O)N(C(=O)C2=C1)C3C(=O)NC(=O)CC3
InChI
1S/C20H23N3O8/c24-16-4-3-15(18(27)22-16)23-19(28)13-2-1-12(11-14(13)20(23)29)21-6-8-31-10-9-30-7-5-17(25)26/h1-2,11,15,21H,3-10H2,(H,25,26)(H,22,24,27)
InChI key
TWTMAVHRHZISKR-UHFFFAOYSA-N
Application
Thalidomide-NH-PEG2-COOH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.
Technology Spotlight:
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Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
pictograms
GHS06,GHS08
signalword
Danger
hcodes
H301,H312,H360D
pcodes
P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIALUPENN-936545-50MG |
|---|---|
| Featured | No |
| Supplier Part Number | 936545-50MG |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |