Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form solid (or Chunk(s)) color off-white to

Name: Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form solid (or Chunk(s)) color off-white to
SKU: SIALUPENN-936553-50MG
Price: 224.00 USD

List Price $224.00 Your Price $224.00

Sigma-Aldrich ligand VH032 Quality Level 100 assay ≥95% form solid (or Chunk(s)) color off-white to light yellow storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-936553-50MG

MFG.PART: 936553-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Description

ligand

VH032

Quality Level

100

assay

≥95%

form

solid (or Chunk(s))

color

off-white to light yellow

storage temp.

2-8°C

SMILES string

C([C@@H](NC(COCCOCCOCCOCCOCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

InChI

1S/C34H50N4O11S/c1-23-30(50-22-36-23)25-7-5-24(6-8-25)18-35-32(43)27-17-26(39)19-38(27)33(44)31(34(2,3)4)37-28(40)20-48-15-13-46-11-9-45-10-12-47-14-16-49-21-29(41)42/h5-8,22,26-27,31,39H,9-21H2,1-4H3,(H,35,43)(H,37,40)(H,41,42)/t26-,27+,31-/m1/s1

InChI key

WLBIKNHFCNHRMV-FMVCKAMOSA-N

Application

(S,R,S)-AHPC-acetamido-O-PEG4-C1-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c