Sigma-Aldrich Quality Level 100 assay ≥95% form crystals (or crystals with chunks) color White to Li

Name: Sigma-Aldrich Quality Level 100 assay ≥95% form crystals (or crystals with chunks) color White to Li
SKU: SIALUPENN-936618-50MG
Price: 263.00 USD

List Price $263.00 Your Price $263.00

Sigma-Aldrich Quality Level 100 assay ≥95% form crystals (or crystals with chunks) color White to Light Yellow storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-936618-50MG

MFG.PART: 936618-50MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥95%

form

crystals (or crystals with chunks)

color

White to Light Yellow

storage temp.

2-8°C

SMILES string

C([C@@H](NC(CCOCCOCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl

InChI

1S/C33H51N5O8S.ClH/c1-23-29(47-22-36-23)25-7-5-24(6-8-25)20-35-31(41)27-19-26(39)21-38(27)32(42)30(33(2,3)4)37-28(40)9-11-43-13-15-45-17-18-46-16-14-44-12-10-34;/h5-8,22,26-27,30,39H,9-21,34H2,1-4H3,(H,35,41)(H,37,40);1H/t26-,27+,30-;/m1./s1

InChI key

XKGVWUPEGSRRJY-ABLBDAGXSA-N

Application

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl is a functionalized functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal amine for conjugation with carboxylic acid linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c