Sigma-Aldrich Quality Level 100 assay ≥95% form powder or crystals color Off White to Yellow to Beig

Name: Sigma-Aldrich Quality Level 100 assay ≥95% form powder or crystals color Off White to Yellow to Beig
SKU: SIALUPENN-936626-100MG
Price: 128.00 USD

List Price $128.00 Your Price $128.00

Sigma-Aldrich Quality Level 100 assay ≥95% form powder or crystals color Off White to Yellow to Beige storage temp. 2-8°C SMILES string - SIALUPENN (Additional S&H or Hazmat Fees may Apply)

NETA PART: SIALUPENN-936626-100MG

MFG.PART: 936626-100MG

UNSPSC: 41122409

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

assay

≥95%

form

powder or crystals

color

Off White to Yellow to Beige

storage temp.

2-8°C

SMILES string

C(OC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1 )=O)CCCNC(N)=0)=O)C(C)C)=O)C3C=4C(C=5C3-CC-CC5)=CC-CC4

InChI

1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55-40(51)56-28-19-17-27(18-20-28)46(52)53/h3-6,8-11,13-20,24,33-35H,7,12,21-23H2,1-2H3,(H,43,47)(H,44,48)(H,45,50)(H3,41,42,49)/t34-,35-/m0/s1

InChI key

USMYACISHVPTHK-PXLJZGITSA-N

Application

This is a cathepsin cleavable linker used in bioconjugation, specifically in the construction of antibody drug conjugates (ADC & Bioconjugation).

Features and Benefits

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers.

Other Notes

ADC & Bioconjugation.

Chemical Biology Tools.

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c