Sigma-Aldrich TISSEUFAB½ NORBORNENE FUNCTIONALIZED PO&

Rethink your bioinks with TissueFab^®

About the material:

These TissueFab^® norbornene functionalized poly(amio acid) is a xeno-free (animal origin free), biodegradable and biocompatible polymer that been developed and tested for hydrogel synthesis for tissue engineering and other biomedical applications. Printing and crosslinking parameters:

• Compatible for cell encapsulation and hydrogel formation.
• Crosslinked via photopolymerization via UV or visible light with suitable photo initiator.

The TissueFab^® norbornene functionalized poly(amino acid) is characterized by its biocompatibility and biodegradability, making it well-suited for a broad spectrum of applications in the biomedical field. This poly(amino acid) is synthesized through the ring opening of polysuccinimide using a nucleophilic reagent. The presence of amide linkages in these polymers results in peptide-like structures that are prone to cleavage and degradation in the body, leading to the formation of amino acids or small peptides.

Furthermore, the norbornene functional group within the polymer provides sites for additional chemical modifications or conjugation with bioactive molecules, such as therapeutics, peptides, and targeted ligands. This versatility enables the incorporation of specific functionalities into the polymer matrix, allowing for the impartation of desired biological or therapeutic properties, such as controlled drug release or cell adhesion. For instance, the norbornene polymer can undergo thiolene reactions with thiolated peptides, thereby eliciting bioactive biochemical cues to encapsulated cells.

More information and a step-by-step protocol can be found under the "More Documents" section of this page.

The TissueFab^® norbornene functionalized poly(amino acid) xeno-free polymer is:

• Biocompatible and biodegradable precursor for hydrogel and bioink development
• Suitable for a wide range of biomedical applications, including 3D cell culture, tissue engineering, in vitro drug screening, and regenerative medicine research
• Enables the development of xeno-free polymers for applications in advanced cell culture and tissue engineering
• Ideal for creating biocompatible materials that support cell growth and tissue regeneration in a xenogeneic-free environment

This TissueFab^® hydrogel and bioink precursor has been developed and tested to meet strict criteria to best suit researchers′ needs. This includes:

• Xeno-free, animal-origin free
• Tunable
• Cell viability
• Biocompatibility and biodegradability
• Mechanical and rheological properties
• Crosslinkability

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany