Revvity HTFF Human Phospho-Tie2 (TYR992) Detection Kit, 50,000 Assay Points

Tie2 is a tyrosine-protein kinase found in endothelial cells, serving as a cell-surface receptor for angiopoietins. It plays a crucial role in regulating angiogenesis, cell migration, survival, adhesion, and proliferation, primarily ensuring vascular stability and maintenance. When Angiopoietin 1 is present, Tie2 receptors form homodimers, leading to the autophosphorylation of the C-terminal tails at Tyrosine 992 and the activation of downstream signaling pathways.