Revvity HTFF Human Phospho-Ire1 (SER724) Detection Kit, 50,000 Assay Points

IRE1 (Inositol requiring enzyme 1 alpha) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway with roles in regulation of ER stress and UPR. IRE1 is encoded by the ERN1 gene and is ubiquitously expressed in mammals. IRE1 is a type I transmembrane protein, exhibiting an ER luminal domain that senses the protein folding status and a catalytic kinase and RNase cytosolic domain. In recent years, IRE1 has emerged as a relevant therapeutic target in various diseases including degenerative disorders, inflammatory and metabolic pathologies, and cancer.