Revvity HTFF Human Phospho-Nucleolin Thr84 Detection Kit, 50,000 Assay Points

Nucleolin is protein mostly localized in the nucleus, where it is involved in ribosome biogenesis by binding to and stabilizing pre-RNA. It also plays several other roles in conjunction with ribosomes, such as RNA transcription regulation via transcription factor binding and nucleus-cytosol mRNA trafficking. The phosphorylation state of nucleolin regulates its activity by increasing its binding affinity for RNA, and is especially enhanced in response to cellular stress and DNA damage. Abnormal phosphorylation of nucleolin is recognized as a potential source of lack of regulation in mRNA transcription, which can alter the expression of pro- and anti-oncogenic genes and contribute to cancer development or progression.