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Revvity HTFF Human And Mouse Total Npm1, Control Lysate
List Price $464.00 Your Price $464.00
Revvity This Lysate Is A Component Of The Total Npm1 Kit - PEMSD (Additional S&H Or Hazmat Fees May Apply)
NETA PART: PEMSD-64NPMTTDA
MFG.PART: 64NPMTTDA
UNSPSC: 41106509
Manufacturer: Revvity
NPM1 (Nucleophosmin 1) is a molecular chaperone involved in cell cycle regulation, ribosome biogenesis, cell proliferation, DNA damage repair, and apoptosis. Its phosphorylation on Thr199 by the CDK2/Cyclin E complex regulates mitosis, centrosome duplication, pre-mRNA processing, and G2/M cell cycle arrest through its interaction with p53/MDM2.
NPM1 functions both as an oncogene and a tumor suppressor. It is frequently overexpressed, altered, and rearranged, or sporadically deleted, in human cancers. NPM1 is also the most frequently mutated gene (NPM1c) in acute myeloid leukemia (AML).
| SKU | PEMSD-64NPMTTDA |
|---|---|
| Supplier Part Number | 64NPMTTDA |
| UM | EA |
| UNSPSC | 41106509 |
| Manufacturer | Revvity |
| CountryOfOrigin | France |
| ProductLine | PEMSD |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 4 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |