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GenScript DNA polymerase theta, 100μg
List Price $300.00 Your Price $300.00
GenScript POLQ is a low-fidelity DNA polymerase with helicase activity that drives MMEJ, an alternative NHEJ pathway.s. It is often overexpressed in cancers with HR defects. - GSCRPT (Additional S&H or Hazmat Fees May Apply)
NETA PART: GSCRPT-RP-D00004-100
MFG.PART: RP-D00004-100
UNSPSC: 12352202
Manufacturer: GenScript USA Inc
Description
Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers. |
Background
| Synonyms | POLH |
Product Introduction
| Species | Homo sapiens |
| Construct | Helicase domain, aa 1-894 |
| Appearance | Clear liquid |
| Accession# | O75417 |
| Purity | ≥ 90% by SDS-PAGE |
| Endotoxin Level | ≤ 100 EU/mg |
| Source | Insect cell Sf9 |
| Theoretical Molecular Weight | 99 kDa |
| Tag | His tag at the N-terminus |
| Application | Drug discovery for cancer therapeutics. In vitro affinity assays, activity assays etc. |
| Formulation | Supplied as a solution of 50 mM Tris, 500 mM NaCl, 5% Glycerol, 2 mM TCEP, pH 8.0 |
| Storage & Stability | This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles. |
| Note | For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden. |
| SKU | GSCRPT-RP-D00004-100 |
|---|---|
| Supplier Part Number | RP-D00004-100 |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | GenScript USA Inc |
| Temperature | -80 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Width | 0.44 |
| Depth | 1.74 |
| Height | 0.44 |
| Weight | 15.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |