SyntIV gp120 glycoprotein of the primary AD8 strain of the human immunodeficiency virus (HIV-1 gp120; 200 micrograms)

SyntIV HIV-1 gp120 from strain AD8, which can infect both T cells and Macrophages. HIV-1 envelope glycoproteins (Envs) mediate HIV-1 entry and they are assembled into a trimer on the viral particle; each unit of the trimer contains the surface gp120 protein non-covalently associated with the transmembrane gp41 protein. HIV-1 AD8 Envs are well expressed, highly stable, and commonly used in non-human primate models of HIV-1 infection. The AD8gp120 contains 475 amino acids and has a calulated molecular weight of 53,418 Da. Due to intensive glycosylations, gp120 migrates with apparent molecular mass of approximately 120 kDa. SyntIV gp120 shows more homegenous glycosylation pattern compared with gp120 produced by transient transfection of HEK293 cells, 200 micrograms - SIV (Additional S&H or Hazmat Fees May Apply)