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Sigma-Aldrich Adenosine A1 Receptor Antagonist I Dpcpx
List Price $98.40 Your Price $98.40
Sigma-Aldrich Adenosine A1 Receptor Antagonist I Dpcpx - SIALUPENN (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALUPENN-119147-25MG
MFG.PART: 119147-25MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Quality Level
100
form
white solid
solubility
soluble (DMSO (5 mM))
storage temp.
2-8°C
SMILES string
CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3
InChI
1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChI key
FFBDFADSZUINTG-UHFFFAOYSA-N
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General description
A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
| SKU | SIALUPENN-119147-25MG |
|---|---|
| Supplier Part Number | 119147-25MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 102146-07-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |