Sigma-Aldrich Spinal Astrocytes Wc-30 Healthy Control&

Human iPSC-Derived Spinal Astrocytes. Required products (sold separately): BX-2600-100uL, BX-2020-100uL. Specialized glia that are the majority of the central nervous system (CNS), astrocytes do not conduct electrical signals but promote the health of the CNS through regulating the blood-brain barrier (BBB), excess neurotransmitter clearance, and maintaining ion balance, and more. Related diseases: ALS, SMA, Spinal Cord Injury.

Function: Spinal Astrocytes promote mature motor neuron activity. Co-culturing motor neurons with spinal astrocytes promotes maximal calcium influx within 10 days. Energy and structural support cell for spinal neurons and immune response. Exhibit earlier and higher levels of synchronous firing when co-cultured with spinal motor neurons.

Marker Expression and Morphology: Fully differentiated Spinal Astrocytes express key astrocyte markers GFAP (green) and S100β (red) at >90% and exhibit mature process-bearing morphologies (shown with a DAPI stain).

Labelling by the spinal-specific marker HOXB4 (red) with a Hoescht stain highlights the regional specificity of the Spinal Astrocytes.