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Sigma-Aldrich Anti-Phospho-Ampk Alpha 2 (Ser491) Anti&
List Price $309.00 Your Price $309.00
Sigma-Aldrich Anti-Phospho-Ampk Alpha 2 (Ser491) Anti& - SIALUPENN (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALUPENN-SAB6012227-100UL
MFG.PART: SAB6012227-100UL
UNSPSC: 41116012
Manufacturer: Sigma-Aldrich
biological source
rabbit (Monoclonal)
Quality Level
100
recombinant
expressed in HEK 293 cells
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
23GB5675, recombinant monoclonal
form
buffered aqueous glycerol solution
mol wt
62 kDa
species reactivity
human
packaging
vial of 1.5 mL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
1.3 mg/ml
technique(s)
flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000
isotype
IgG
Ensembl | human accession no.
ENSG00000162409
NCBI accession no.
NP_006243.2
UniProt accession no.
P54646
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRKAA2(5563)
General description
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
Immunogen
A synthesized peptide corresponding to a sequence within amino acids 484-498 of human AMPK alpha 2 [NP_006243.2].
Physical form
Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Other Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
| SKU | SIALUPENN-SAB6012227-100UL |
|---|---|
| Supplier Part Number | SAB6012227-100UL |
| UM | EA |
| UNSPSC | 41116012 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |