Sigma-Aldrich Streptozocin Ready Made Solution

biological source

synthetic

Quality Level

200

assay

≥97% (HPLC)

form

liquid
ready-to-use solution

storage condition

(Light Sensitive)

concentration

20 mg/mL (in citrate buffer (pH=4.5))

color

colorless to yellow

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

InChI

InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

• As an antibiotic4 and antineoplastic agent.
• As a toxic to insulin producing β-cells of pancreas in mammals[4] The relative toxicity to β-cells is occurring because of the similarity of STZ to glucose, as it transported into the cells by glucose transport protein, GLUT2, which is highly expressed on β-cells.[1][2]
• For treating cancer of Islets of Langerhans and to produce animal models of type 1, diabetes.[4][5]
• To induce diabetes in rats.[6][7][8][9][10][11]It is injected at 60-100mg/Kg to induce diabetes in rats model.