Sigma-Aldrich Ly341495

Potent antagonist against group IImetabotropic glutamate receptors mGluR2 and mGluR3. LY341495 (LY 341495,LY-341,495, LY-341495) is a group II metabotropic glutamate receptor antagonistthat potently reverses 3 μM mGluR agonist ACPD-dependent inhibition of forskolin-induced cAMP production in cells expressing either human mGluR2 or mGluR3 (IC50 = 21 nM and 14 nM, respectively), being much less potent against mGluR8, mGluR7, mGluR1a, mGluR5a, and mGluR4 (IC50 = 0.17, 0.99, 7.8, 8.2, 22μM, respectively). LY341495 is widely used for studying mGluR2/3-dependent cellular and physiological functions both in cultures in vitro and in animalsin vivo (1-10 mg/kg via i.p. or s.c.).

LY341495 is suitable for use as a metabotropicglutamate receptor antagonist to study the role of glutamate signaling invarious physiological and pathological processes. It is used in neurobiology studies, particularly inunderstanding the mechanisms underlying synaptic transmission/ neurotransmitterrelease, synaptic plasticity and neuronal excitability.