Sigma-Aldrich At2R Agonist C21

Potent and selective angiotensin II receptor (AT2R) nonpeptide agonist in vitro and in vivo.


C21 (Buloxibutid; Compound 21; M024) is a potent and selective angiotensin II receptor (AT2R) nonpeptide agonist (Ki = 0.4 nM/AT1R vs. >10 µM/AT1R) that induces AT2R-mediated morphological changes in NG 108-15 neuroblastoma-glioma hybrid cells (100 nM for 3 days), blockable by AT2R antagonist PD 123,319 (1 µM). C21 enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats (30 & 300 µg/kg/h via i.v.), and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats in vivo (50 µg/kg/h via i.v.).