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Sigma-Aldrich Idelalisib
List Price $439.00 Your Price $439.00
Sigma-Aldrich Idelalisib - SIALUPENN (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALUPENN-SML4246-250MG
MFG.PART: SML4246-250MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Orally active, potent and subtype-selective phosphatidylinositol-3-kinase p110delta (PI3Kδ) inhibitor in vitro and in vivo.
Idelalisib (CAL-101; GS-1101) is an orally active, potent and subtype-selective phosphatidylinositol-3-kinase p110delta (PI3Kδ) inhibitor (PI3Kδ/γ/β/α IC50 = 2.5/89/565/820 nM, IC50 = 978 nM/hVPS34, 6.73 µM/DNA-PK, >1 µM/CIIβ & mTOR) that induces apoptosis in diffuse large B-cell lymphoma, follicular lymphoma, and B-ALL cell cultures (0.5-1 µM for 24h) by blocking constitutive PI3K pathway activation.
Idelalisib (CAL-101; GS-1101) is an orally active, potent and subtype-selective phosphatidylinositol-3-kinase p110delta (PI3Kδ) inhibitor (PI3Kδ/γ/β/α IC50 = 2.5/89/565/820 nM, IC50 = 978 nM/hVPS34, 6.73 µM/DNA-PK, >1 µM/CIIβ & mTOR) that induces apoptosis in diffuse large B-cell lymphoma, follicular lymphoma, and B-ALL cell cultures (0.5-1 µM for 24h) by blocking constitutive PI3K pathway activation.
| SKU | SIALUPENN-SML4246-250MG |
|---|---|
| Supplier Part Number | SML4246-250MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 870281-82-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |