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Sigma-Aldrich Cgp 78608 Hydrochloride
List Price $214.00 Your Price $214.00
Sigma-Aldrich Cgp 78608 Hydrochloride - SIALUPENN (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALUPENN-SML4035-5MG
MFG.PART: SML4035-5MG
UNSPSC: 51000000
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥97%
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
SMILES string
BrC1=CC(NC2=O)=C(C(CN[C@@H](P(O)(O)=O)C)=C1)NC2=O.Cl
Biochem/physiol Actions
Potent glycine site-selective NMDA receptor antagonist with anticonvulsant efficacy in vivo.
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
Disclaimer
Hygroscopic
| SKU | SIALUPENN-SML4035-5MG |
|---|---|
| Supplier Part Number | SML4035-5MG |
| UM | EA |
| UNSPSC | 51000000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALUPENN |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 1135278-54-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |